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EFM2 protein (Saccharomyces cerevisiae) - STRING interaction network
"EFM2" - S-adenosylmethionine-dependent methyltransferase in Saccharomyces cerevisiae
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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EFM2S-adenosylmethionine-dependent methyltransferase; belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 2 (EFT1/EFT2) at ’Lys-613’ and methylates elongation factor 3A (YEF3) (419 aa)    
Predicted Functional Partners:
EFM3
Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono-, di- and trimethylates elongation factor 2 (EFT1/EFT2) at ’Lys-509’ (339 aa)
       
 
  0.948
EFM1
Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at ’Lys-30’ (585 aa)
     
   
  0.902
BMT5
Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of uridine 2634 (m3U2634) in 25S rRNA (336 aa)
     
   
  0.888
BMT2
Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit (337 aa)
     
   
  0.886
REX4
Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (289 aa)
   
   
  0.843
SSF1
Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; Required for biogenesis of the 60S ribosomal subunit (453 aa)
     
        0.841
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; Involved in rRNA-processing and ribosome biogenesis (254 aa)
     
        0.836
YBL028C
Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis (106 aa)
     
   
  0.827
TRM112
Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase MTQ2, required for the methylation of eRF1 on ’Gln-182’. Together with methyltransferase TRM11, required for the formation of 2- methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase BUD23, required for the formation of 7- methylguanin [...] (135 aa)
     
 
  0.822
HPM1
AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance; Required for histidine methylation of RPL3 at ’His-243’ (377 aa)
     
   
  0.820
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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