| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CEG1 | CET1 | YGL130W | YPL228W | mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant. | mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant. | 0.999 |
| CEG1 | CTP1 | YGL130W | YBR291C | mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant. | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | 0.701 |
| CET1 | CEG1 | YPL228W | YGL130W | mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant. | mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant. | 0.999 |
| CET1 | CTP1 | YPL228W | YBR291C | mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant. | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | 0.702 |
| CTP1 | CEG1 | YBR291C | YGL130W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant. | 0.701 |
| CTP1 | CET1 | YBR291C | YPL228W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant. | 0.702 |
| CTP1 | GCN2 | YBR291C | YDR283C | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control. | 0.782 |
| CTP1 | LYS20 | YBR291C | YDL182W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. | 0.835 |
| CTP1 | MAE1 | YBR291C | YKL029C | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. | 0.772 |
| CTP1 | RAD50 | YBR291C | YNL250W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | DNA repair protein RAD50; Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress; Belongs to the SMC family. RAD50 subfamily. | 0.777 |
| CTP1 | SPC1 | YBR291C | YJR010C-A | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress. | 0.727 |
| CTP1 | SSD1 | YBR291C | YDR293C | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Protein SSD1; Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function; Belongs to the RNR ribonuclease family. | 0.778 |
| CTP1 | TSR2 | YBR291C | YLR435W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Pre-rRNA-processing protein TSR2; Protein with a potential role in pre-rRNA processing; Belongs to the TSR2 family. | 0.710 |
| CTP1 | VID30 | YBR291C | YGL227W | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | Vacuolar import and degradation protein 30; Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm. | 0.801 |
| GCN2 | CTP1 | YDR283C | YBR291C | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control. | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | 0.782 |
| GCN2 | LYS20 | YDR283C | YDL182W | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control. | Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. | 0.841 |
| GCN2 | SSD1 | YDR283C | YDR293C | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control. | Protein SSD1; Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function; Belongs to the RNR ribonuclease family. | 0.536 |
| LYS20 | CTP1 | YDL182W | YBR291C | Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | 0.835 |
| LYS20 | GCN2 | YDL182W | YDR283C | Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control. | 0.841 |
| MAE1 | CTP1 | YKL029C | YBR291C | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. | 0.772 |
