node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADF1 | AUA1 | YCL058W-A | YFL010W-A | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease | 0.744 |
ADF1 | FYV5 | YCL058W-A | YCL058C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.747 |
ADF1 | HMLALPHA2 | YCL058W-A | YCL067C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | 0.526 |
ADF1 | IMO32 | YCL058W-A | YGR031W | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | Abhydrolase domain-containing protein IMO32; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1; Belongs to the AB hydrolase superfamily | 0.711 |
ADF1 | MATALPHA2 | YCL058W-A | YCR039C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | Silenced mating-type protein ALPHA2; Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette | 0.555 |
AIM26 | FYV5 | YKL037W | YCL058C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.569 |
AIM26 | FYV7 | YKL037W | YLR068W | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin | 0.672 |
AUA1 | ADF1 | YFL010W-A | YCL058W-A | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | 0.744 |
AUA1 | FYV5 | YFL010W-A | YCL058C | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.572 |
AUA1 | IMO32 | YFL010W-A | YGR031W | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease | Abhydrolase domain-containing protein IMO32; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1; Belongs to the AB hydrolase superfamily | 0.712 |
BRP1 | FYV5 | YGL007W | YCL058C | Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1 | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.527 |
BSC4 | FYV5 | YNL269W | YCL058C | Bypass of stop codon protein 4; Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.812 |
CMR3 | FYV5 | YPR013C | YCL058C | Putative zinc finger protein; YPR013C is not an essential gene | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | 0.554 |
CMR3 | FYV7 | YPR013C | YLR068W | Putative zinc finger protein; YPR013C is not an essential gene | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin | 0.650 |
FYV5 | ADF1 | YCL058C | YCL058W-A | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand | 0.747 |
FYV5 | AIM26 | YCL058C | YKL037W | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT | 0.569 |
FYV5 | AUA1 | YCL058C | YFL010W-A | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease | 0.572 |
FYV5 | BRP1 | YCL058C | YGL007W | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1 | 0.527 |
FYV5 | BSC4 | YCL058C | YNL269W | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Bypass of stop codon protein 4; Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment | 0.812 |
FYV5 | CMR3 | YCL058C | YPR013C | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis | Putative zinc finger protein; YPR013C is not an essential gene | 0.554 |