node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMLALPHA1 | HMLALPHA2 | YCL066W | YCL067C | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | 0.991 |
HMLALPHA1 | HMRA1 | YCL066W | YCR097W | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Silenced mating-type protein a1; Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells | 0.909 |
HMLALPHA1 | MATALPHA2 | YCL066W | YCR039C | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Silenced mating-type protein ALPHA2; Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette | 0.945 |
HMLALPHA1 | MCM1 | YCL066W | YMR043W | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia | 0.957 |
HMLALPHA1 | MF(ALPHA)1 | YCL066W | YPL187W | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions | 0.971 |
HMLALPHA1 | MF(ALPHA)2 | YCL066W | YGL089C | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions | 0.901 |
HMLALPHA1 | SAG1 | YCL066W | YJR004C | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor; To C.albicans ALS1 | 0.873 |
HMLALPHA1 | STE12 | YCL066W | YHR084W | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Protein STE12; Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth | 0.895 |
HMLALPHA1 | STE3 | YCL066W | YKL178C | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR | 0.971 |
HMLALPHA1 | YCR041W | YCL066W | YCR041W | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | Uncharacterized protein YCR041W; Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p | 0.872 |
HMLALPHA2 | HMLALPHA1 | YCL067C | YCL066W | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | 0.991 |
HMLALPHA2 | HMRA1 | YCL067C | YCR097W | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Silenced mating-type protein a1; Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells | 0.999 |
HMLALPHA2 | MATALPHA2 | YCL067C | YCR039C | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Silenced mating-type protein ALPHA2; Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette | 0.802 |
HMLALPHA2 | MCM1 | YCL067C | YMR043W | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia | 0.997 |
HMLALPHA2 | MF(ALPHA)1 | YCL067C | YPL187W | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions | 0.528 |
HMLALPHA2 | STE12 | YCL067C | YHR084W | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Protein STE12; Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth | 0.681 |
HMLALPHA2 | STE3 | YCL067C | YKL178C | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR | 0.726 |
HMRA1 | HMLALPHA1 | YCR097W | YCL066W | Silenced mating-type protein a1; Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells | Transcriptional co-activator mating type protein alpha; Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression | 0.909 |
HMRA1 | HMLALPHA2 | YCR097W | YCL067C | Silenced mating-type protein a1; Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Belongs to the TALE/M-ATYP homeobox family | 0.999 |
HMRA1 | MATALPHA2 | YCR097W | YCR039C | Silenced mating-type protein a1; Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells | Silenced mating-type protein ALPHA2; Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette | 0.983 |