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VBA3 protein (Saccharomyces cerevisiae) - STRING interaction network
"VBA3" - Permease of basic amino acids in the vacuolar membrane in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
VBA3Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine and lysine (458 aa)    
Predicted Functional Partners:
VBA1
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of at least histidine and lysine (562 aa)
   
 
 
  0.924
YPQ1
Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole (308 aa)
           
  0.890
RTC2
Protein of unknown function; mutant produces large lipid droplets, is resistant to fluconazole, has decreased levels of rDNA transcription, growth defects on minimal media, and suppresses cdc13-1; detected in highly purified mitochondria; similar to /.../rotein coupled receptor from S. pombe; May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium (296 aa)
           
  0.843
AMF1
Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug-H+ antiporters; YOR378W is not an essential gene; Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell (515 aa)
   
     
  0.718
VBA2
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine (474 aa)
   
 
 
0.714
GEX1
Proton-glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway (615 aa)
     
   
  0.664
ATR1
Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; Putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. Probable ATP-dependent export permease. Appears to confer resistance only to aminotriazole (542 aa)
   
     
  0.662
VBA4
Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene; Transporter required for vacuolar uptake of basic amino acids (768 aa)
           
  0.620
ERS1
Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; Transport cystine out of vacuoles/endodomes (260 aa)
       
 
  0.615
YCL068C
Putative protein of unknown function (260 aa)
     
   
  0.577
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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