| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PUF3 | RMD1 | YLL013C | YDL001W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Cytoplasmic protein required for sporulation. | 0.808 |
| PUF3 | SAP185 | YLL013C | YJL098W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication; Belongs to the SAPS family. | 0.514 |
| PUF3 | YBT1 | YLL013C | YLL048C | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | ATP-dependent bile acid permease; Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication. | 0.488 |
| PUF3 | YCK3 | YLL013C | YER123W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Casein kinase I homolog 3; Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. | 0.475 |
| PUF3 | YDL206W | YLL013C | YDL206W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.802 |
| RMD1 | PUF3 | YDL001W | YLL013C | Cytoplasmic protein required for sporulation. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.808 |
| RMD1 | SAP185 | YDL001W | YJL098W | Cytoplasmic protein required for sporulation. | SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication; Belongs to the SAPS family. | 0.817 |
| RMD1 | SYG1 | YDL001W | YIL047C | Cytoplasmic protein required for sporulation. | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | 0.791 |
| RMD1 | VTC2 | YDL001W | YFL004W | Cytoplasmic protein required for sporulation. | Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication; Belongs to the VTC2/3 family. | 0.769 |
| RMD1 | VTC5 | YDL001W | YDR089W | Cytoplasmic protein required for sporulation. | Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress. | 0.809 |
| RMD1 | YBT1 | YDL001W | YLL048C | Cytoplasmic protein required for sporulation. | ATP-dependent bile acid permease; Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication. | 0.747 |
| RMD1 | YCK3 | YDL001W | YER123W | Cytoplasmic protein required for sporulation. | Casein kinase I homolog 3; Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. | 0.731 |
| RMD1 | YDL206W | YDL001W | YDL206W | Cytoplasmic protein required for sporulation. | Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.762 |
| RMD1 | YJL163C | YDL001W | YJL163C | Cytoplasmic protein required for sporulation. | Uncharacterized membrane protein YJL163C; Putative protein of unknown function. | 0.743 |
| RMD1 | YPK9 | YDL001W | YOR291W | Cytoplasmic protein required for sporulation. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.902 |
| SAP185 | PUF3 | YJL098W | YLL013C | SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication; Belongs to the SAPS family. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.514 |
| SAP185 | RMD1 | YJL098W | YDL001W | SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication; Belongs to the SAPS family. | Cytoplasmic protein required for sporulation. | 0.817 |
| SYG1 | RMD1 | YIL047C | YDL001W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Cytoplasmic protein required for sporulation. | 0.791 |
| SYG1 | VTC2 | YIL047C | YFL004W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication; Belongs to the VTC2/3 family. | 0.857 |
| SYG1 | VTC5 | YIL047C | YDR089W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress. | 0.797 |
