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KNH1 protein (Saccharomyces cerevisiae) - STRING interaction network
"KNH1" - Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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KNH1Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance; Involved in cell wall beta(1->6) glucan synthesis (268 aa)    
Predicted Functional Partners:
KRE5
Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; Required for (1->6)-beta-D-glucan synthesis and normal cell growth (1365 aa)
           
  0.697
YIL029C
Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) (142 aa)
           
  0.697
KEG1
Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability; Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability (200 aa)
           
  0.678
SKN1
Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p; Required for synthesis of the major beta-glucans of the yeast cell wall (771 aa)
           
  0.626
KRE6
Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; Involved in the synthesis of (1->6)- and (1->3)-beta-D- glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-struc [...] (720 aa)
           
  0.579
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor; Involved in a late stage of cell wall 1,6-beta-glucan synthesis and assembly. Has a structural, rather than enzymic, function within cell wall 1,6-beta-glucan assembly and architecture, possibly by being involved in covalently cross- linking 1,6-beta-glucans to other cell wall components such as 1,3-beta-glucan, chitin and certain mannoproteins. Acts as the plasma membrane receptor for the yeast K1 viral toxin (313 aa)
           
  0.544
CWH41
Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed-9363442). Seems to play a role in beta-1,6- glucan synthesis (PubMed-8576053) (833 aa)
           
  0.489
BIG1
Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan; Required for normal beta-1,6-glucan synthesis (335 aa)
           
  0.446
FKS1
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling (1876 aa)
           
  0.416
KRE9
Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects; Involved in cell wall beta(1->6) glucan synthesis (276 aa)
       
 
0.407
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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