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CBS1 protein (Saccharomyces cerevisiae) - STRING interaction network
"CBS1" - Mitochondrial translational activator of the COB mRNA in Saccharomyces cerevisiae
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Predicted Interactions
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CBS1Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5’-untranslated leader; mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur (229 aa)    
Predicted Functional Partners:
CBS2
Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5’-untranslated leader; Translational activator of cytochrome b. The cytochrome b (coB) leader RNA may represent the target sequence for CBS1 and/ or CBS2 (389 aa)
           
  0.922
CBP6
Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly /.../sized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; This protein is involved in processing of the 5’ terminus and the intervening sequences of cytochrome b pre-mRNA (162 aa)
       
 
  0.701
PET494
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane; Required for the expression of the mitochondrial gene for cytochrome c oxidase subunit III (COX3) (489 aa)
           
  0.637
COB
Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c (385 aa)
           
  0.637
MSS51
Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregatio [...] (436 aa)
           
  0.626
PET309
Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1 (965 aa)
           
  0.580
CBP1
Mitochondrial protein that interacts with the 5’-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p; Responsible for conferring a stable 5’-end on cytochrome b mRNA (654 aa)
           
  0.580
PET111
Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane; Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2) (800 aa)
           
  0.578
PET54
Mitochondrial inner membrane protein; binds to the 5’ UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3 (293 aa)
           
  0.578
PET122
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane; Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA (254 aa)
           
  0.571
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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