node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | BEM1 | YFL039C | YBR200W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | 0.976 |
ACT1 | CDC42 | YFL039C | YLR229C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | 0.989 |
ACT1 | GDI1 | YFL039C | YER136W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Rab GDP-dissociation inhibitor; GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins. | 0.466 |
ACT1 | RDI1 | YFL039C | YDL135C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress. | 0.855 |
ACT1 | RGA1 | YFL039C | YOR127W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication. | 0.679 |
ACT1 | RHO1 | YFL039C | YPR165W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p). | 0.978 |
ACT1 | RHO2 | YFL039C | YNL090W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly. | 0.771 |
ACT1 | RHO3 | YFL039C | YIL118W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein RHO3; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p. | 0.836 |
ACT1 | RHO4 | YFL039C | YKR055W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein RHO4; Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi. | 0.819 |
ACT1 | RHO5 | YFL039C | YNL180C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein RHO5; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; RAC1 ortholog; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity. | 0.715 |
BEM1 | ACT1 | YBR200W | YFL039C | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.976 |
BEM1 | CDC42 | YBR200W | YLR229C | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | 0.999 |
BEM1 | RDI1 | YBR200W | YDL135C | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress. | 0.855 |
BEM1 | RGA1 | YBR200W | YOR127W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication. | 0.897 |
BEM1 | RHO1 | YBR200W | YPR165W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p). | 0.770 |
BEM1 | RHO2 | YBR200W | YNL090W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly. | 0.485 |
BEM1 | RHO3 | YBR200W | YIL118W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTP-binding protein RHO3; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p. | 0.928 |
BEM1 | RHO4 | YBR200W | YKR055W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTP-binding protein RHO4; Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi. | 0.771 |
BEM1 | RHO5 | YBR200W | YNL180C | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p. | GTP-binding protein RHO5; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; RAC1 ortholog; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity. | 0.616 |
CDC42 | ACT1 | YLR229C | YFL039C | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.989 |