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MHF2 protein (Saccharomyces cerevisiae) - STRING interaction network
"MHF2" - Putative protein of unknown function in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MHF2Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability; DNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (PubMed-20347428). FANCM- MHF promotes gene conversion at blocked replication forks (By similarity) (80 aa)    
Predicted Functional Partners:
MHF1
Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (PubMed-20347428). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity) (90 aa)
       
    0.988
ELG1
Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re- start, recombination and repair (791 aa)
       
      0.652
TFB5
Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair; Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. TFB5 is required for stab [...] (72 aa)
     
   
  0.555
SRS2
DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability; ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. The polarity of the helicase activity was determined to be 3’ to 5’ (1174 aa)
       
      0.524
YCL049C
Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene (312 aa)
           
  0.520
YDR089W
Protein of unknown function; deletion confers resistance to Nickel (869 aa)
           
  0.516
LDB17
Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck; May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface (491 aa)
           
  0.487
SNA4
Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated (140 aa)
           
  0.480
RRG1
Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification (365 aa)
           
  0.454
ERP6
Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Involved in vesicular protein trafficking (216 aa)
           
  0.449
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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