node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH6 | YDL177C | YMR318C | YDL177C | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.759 |
BIO4 | DFR1 | YNR057C | YOR236W | Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels. | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | 0.498 |
BIO4 | YDL177C | YNR057C | YDL177C | Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.488 |
CDC8 | DFR1 | YJR057W | YOR236W | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant. | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | 0.863 |
CDC8 | DUT1 | YJR057W | YBR252W | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid. | 0.979 |
CDC8 | YDL177C | YJR057W | YDL177C | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.523 |
DFR1 | BIO4 | YOR236W | YNR057C | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels. | 0.498 |
DFR1 | CDC8 | YOR236W | YJR057W | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant. | 0.863 |
DFR1 | DUT1 | YOR236W | YBR252W | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid. | 0.843 |
DFR1 | GCV3 | YOR236W | YAL044C | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; Belongs to the GcvH family. | 0.832 |
DFR1 | YDL177C | YOR236W | YDL177C | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.488 |
DUT1 | CDC8 | YBR252W | YJR057W | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid. | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant. | 0.979 |
DUT1 | DFR1 | YBR252W | YOR236W | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid. | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | 0.843 |
DUT1 | YDL177C | YBR252W | YDL177C | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.496 |
GCV3 | DFR1 | YAL044C | YOR236W | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; Belongs to the GcvH family. | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. | 0.832 |
GCV3 | YDL177C | YAL044C | YDL177C | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; Belongs to the GcvH family. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.461 |
USE1 | YDL177C | YGL098W | YDL177C | Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.481 |
YAR047C | YDL177C | YAR047C | YDL177C | Putative uncharacterized membrane protein YAR047C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | 0.840 |
YAR047C | YMR317W | YAR047C | YMR317W | Putative uncharacterized membrane protein YAR047C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Uncharacterized protein YMR317W; Putative protein of unknown function; has some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene. | 0.410 |
YDL177C | ADH6 | YDL177C | YMR318C | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | 0.759 |