| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EST1 | YDL180W | YLR233C | YDL180W | Telomere elongation protein EST1; TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication. | Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.710 |
| MCH1 | RMD1 | YDL054C | YDL001W | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Cytoplasmic protein required for sporulation. | 0.541 |
| MCH1 | YDL180W | YDL054C | YDL180W | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.571 |
| MCH1 | YDL199C | YDL054C | YDL199C | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Putative metabolite transport protein YDL199C; Putative transporter; member of the sugar porter family; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.468 |
| MCH1 | YDL206W | YDL054C | YDL206W | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.557 |
| MCH1 | YJL163C | YDL054C | YJL163C | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Uncharacterized membrane protein YJL163C; Putative protein of unknown function. | 0.582 |
| MCH1 | YJR124C | YDL054C | YJR124C | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Uncharacterized membrane protein YJR124C; Putative protein of unknown function; expression induced under calcium shortage. | 0.461 |
| MCH1 | YML018C | YDL054C | YML018C | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | Uncharacterized vacuolar membrane protein YML018C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication; Belongs to the TPT transporter family. | 0.522 |
| RMD1 | MCH1 | YDL001W | YDL054C | Cytoplasmic protein required for sporulation. | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. | 0.541 |
| RMD1 | SYG1 | YDL001W | YIL047C | Cytoplasmic protein required for sporulation. | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | 0.791 |
| RMD1 | VTC5 | YDL001W | YDR089W | Cytoplasmic protein required for sporulation. | Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress. | 0.809 |
| RMD1 | YDL180W | YDL001W | YDL180W | Cytoplasmic protein required for sporulation. | Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.679 |
| RMD1 | YDL199C | YDL001W | YDL199C | Cytoplasmic protein required for sporulation. | Putative metabolite transport protein YDL199C; Putative transporter; member of the sugar porter family; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.542 |
| RMD1 | YDL206W | YDL001W | YDL206W | Cytoplasmic protein required for sporulation. | Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.762 |
| RMD1 | YJL163C | YDL001W | YJL163C | Cytoplasmic protein required for sporulation. | Uncharacterized membrane protein YJL163C; Putative protein of unknown function. | 0.743 |
| RMD1 | YJR124C | YDL001W | YJR124C | Cytoplasmic protein required for sporulation. | Uncharacterized membrane protein YJR124C; Putative protein of unknown function; expression induced under calcium shortage. | 0.646 |
| RMD1 | YML018C | YDL001W | YML018C | Cytoplasmic protein required for sporulation. | Uncharacterized vacuolar membrane protein YML018C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication; Belongs to the TPT transporter family. | 0.654 |
| SYG1 | RMD1 | YIL047C | YDL001W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Cytoplasmic protein required for sporulation. | 0.791 |
| SYG1 | VTC5 | YIL047C | YDR089W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress. | 0.797 |
| SYG1 | YDL180W | YIL047C | YDL180W | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. | Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.666 |
