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ADY3 protein (Saccharomyces cerevisiae) - STRING interaction network
"ADY3" - Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components in Saccharomyces cerevisiae
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Predicted Interactions
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ADY3Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; Involved in the pathway that organizes the prospore membrane (PSM) during sporulation. Mediates the assembly of the DON1 ring structure at the leading edge of PSM during meiosis II. May constitute a physical link between SSP1-containing PSM precursors and the spindle pole body (SPB) and may facilitate the recruitment of other factors that are required t [...] (790 aa)    
Predicted Functional Partners:
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; Involved in the pathway that organizes the prospore membrane (PSM) during sporulation (365 aa)
       
 
  0.891
SPO21
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May provide a meiosis-specific scaffold for the assembly of other proteins on spindle pole bodies (SPBs), and may be a limiting component for SPB formation (609 aa)
       
 
  0.891
SMA2
Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (369 aa)
       
 
  0.781
MPC54
Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation (464 aa)
       
 
  0.776
SSP1
Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required for the formation of ADY3 and DON1-containing protein coats at the leading edge of the PSMs during meiosis II (571 aa)
       
 
  0.764
CNM67
Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Required for the proper formation of the spindle pole body (SPB) outer plaque. May connect the outer plaque to the central plaque embedded in the nuclear envelope (581 aa)
       
 
  0.755
SPC42
Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane; Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane (363 aa)
       
 
  0.728
AIM23
Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss (356 aa)
       
      0.699
PDB1
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (366 aa)
       
      0.699
SPO1
Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B; Regulates spindle pole duplication in meiosis I, but not in mitosis. Required for meiosis I, meiosis II chromosome segregation and spore formation. Binds phosphatidylinositol (4)P mono- and polyphosphates (631 aa)
       
 
  0.683
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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