| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DBF4 | RTR2 | YDR052C | YDR066C | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | 0.733 |
| DBF4 | STN1 | YDR052C | YDR082W | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | 0.577 |
| DBF4 | YDR042C | YDR052C | YDR042C | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | 0.457 |
| DBF4 | YDR048C | YDR052C | YDR048C | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.504 |
| DBF4 | YDR053W | YDR052C | YDR053W | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | Putative protein of unknown function; open reading frame overlaps 5’ end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex | 0.910 |
| RTR2 | DBF4 | YDR066C | YDR052C | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | 0.733 |
| RTR2 | STN1 | YDR066C | YDR082W | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | 0.887 |
| RTR2 | YDR042C | YDR066C | YDR042C | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | 0.401 |
| RTR2 | YDR048C | YDR066C | YDR048C | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.709 |
| RTR2 | YDR053W | YDR066C | YDR053W | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | Putative protein of unknown function; open reading frame overlaps 5’ end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex | 0.856 |
| STN1 | DBF4 | YDR082W | YDR052C | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | 0.577 |
| STN1 | RTR2 | YDR082W | YDR066C | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | 0.887 |
| STN1 | YDR042C | YDR082W | YDR042C | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | 0.440 |
| STN1 | YDR048C | YDR082W | YDR048C | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.624 |
| STN1 | YDR053W | YDR082W | YDR053W | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | Putative protein of unknown function; open reading frame overlaps 5’ end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex | 0.822 |
| YDR042C | DBF4 | YDR042C | YDR052C | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subuni [...] | 0.457 |
| YDR042C | RTR2 | YDR042C | YDR066C | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1 | 0.401 |
| YDR042C | STN1 | YDR042C | YDR082W | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13 | 0.440 |
| YDR042C | YDR048C | YDR042C | YDR048C | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.440 |
| YDR042C | YDR053W | YDR042C | YDR053W | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant | Putative protein of unknown function; open reading frame overlaps 5’ end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex | 0.491 |
