node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOS2 | J1120 | YDR068W | YJL064W | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 | 0.843 |
DOS2 | OCA6 | YDR068W | YDR067C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT | 0.808 |
DOS2 | ROX1 | YDR068W | YPR065W | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | 0.746 |
DOS2 | RTR2 | YDR068W | YDR066C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | RNA polymerase II subunit B1 CTD phosphatase RTR2; Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication; Belongs to the RPAP2 family | 0.770 |
DOS2 | VBA5 | YDR068W | YKR105C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Vacuolar basic amino acid transporter 5; Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication | 0.779 |
DOS2 | YER134C | YDR068W | YER134C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene; Belongs to the HAD-like hydrolase superfamily | 0.910 |
DOS2 | YGR259C | YDR068W | YGR259C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Putative uncharacterized protein YGR259C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W | 0.919 |
DOS2 | YNR063W | YDR068W | YNR063W | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Uncharacterized transcriptional regulatory protein YNR063W; Putative zinc-cluster protein of unknown function | 0.913 |
DOS2 | YOR292C | YDR068W | YOR292C | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Vacuolar membrane protein YOR292C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; Belongs to the peroxisomal membrane protein PXMP2/4 family | 0.745 |
DOS2 | YPL062W | YDR068W | YPL062W | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | Uncharacterized protein YPL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation | 0.779 |
J1120 | DOS2 | YJL064W | YDR068W | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | 0.843 |
J1120 | ROX1 | YJL064W | YPR065W | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | 0.765 |
J1120 | YPL062W | YJL064W | YPL062W | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 | Uncharacterized protein YPL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation | 0.931 |
OCA6 | DOS2 | YDR067C | YDR068W | Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | 0.808 |
OCA6 | RTR2 | YDR067C | YDR066C | Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT | RNA polymerase II subunit B1 CTD phosphatase RTR2; Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication; Belongs to the RPAP2 family | 0.968 |
ROX1 | DOS2 | YPR065W | YDR068W | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | Protein dos2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | 0.746 |
ROX1 | J1120 | YPR065W | YJL064W | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 | 0.765 |
ROX1 | VBA5 | YPR065W | YKR105C | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | Vacuolar basic amino acid transporter 5; Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication | 0.451 |
ROX1 | YER134C | YPR065W | YER134C | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene; Belongs to the HAD-like hydrolase superfamily | 0.705 |
ROX1 | YGR259C | YPR065W | YGR259C | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance | Putative uncharacterized protein YGR259C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W | 0.744 |