node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | ARP10 | YFL039C | YDR106W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | 0.972 |
ACT1 | ARP2 | YFL039C | YDL029W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.992 |
ACT1 | ARP3 | YFL039C | YJR065C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity. | 0.994 |
ACT1 | ARP4 | YFL039C | YJL081C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.999 |
ACT1 | CAP2 | YFL039C | YIL034C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress. | 0.961 |
ACT1 | EMC10 | YFL039C | YDR056C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein. | 0.923 |
ACT1 | JNM1 | YFL039C | YMR294W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B. | 0.961 |
ACT1 | NIP100 | YFL039C | YPL174C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued). | 0.450 |
ARP1 | ARP10 | YHR129C | YDR106W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | 0.996 |
ARP1 | ARP2 | YHR129C | YDL029W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.923 |
ARP1 | ARP3 | YHR129C | YJR065C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity. | 0.923 |
ARP1 | ARP4 | YHR129C | YJL081C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.936 |
ARP1 | CAP2 | YHR129C | YIL034C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress. | 0.850 |
ARP1 | EMC10 | YHR129C | YDR056C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein. | 0.920 |
ARP1 | JNM1 | YHR129C | YMR294W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B. | 0.999 |
ARP1 | LDB18 | YHR129C | YLL049W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Protein LDB18; Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24. | 0.975 |
ARP1 | NIP100 | YHR129C | YPL174C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued). | 0.998 |
ARP10 | ACT1 | YDR106W | YFL039C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.972 |
ARP10 | ARP1 | YDR106W | YHR129C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | 0.996 |
ARP10 | ARP2 | YDR106W | YDL029W | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.867 |