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GIR2 protein (Saccharomyces cerevisiae) - STRING interaction network
"GIR2" - Highly-acidic cytoplasmic RWD domain-containing protein of unknown function in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GIR2Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein; Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells (PubMed-19448108) (265 aa)    
Predicted Functional Partners:
RBG2
Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; Involved in ribosomal function (368 aa)
     
 
  0.999
RBG1
Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; Involved in ribosomal function (369 aa)
     
 
  0.995
GCN1
Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation (PubMed-8497269, PubMed-24333428). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of GCN2, and hence stimulating GCN2 kinase activity (PubMed-7621 [...] (2672 aa)
       
 
  0.976
ISR1
Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C; Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway that is presumed to be required for the tolerance to high temperatures and staurosporine (443 aa)
       
      0.868
TMA46
Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p (345 aa)
     
 
  0.802
ESF1
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels; Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (628 aa)
     
      0.777
MTG2
Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; Required for mitochondrial protein synthesis. May be involved in mitochondrial ribosome biogenesis (518 aa)
           
  0.726
BUD4
Involved in bud-site selection and required for the axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; required for the formation of a double septin ring, and generall /.../the organization of septin structures; potential Cdc28p substrate; Required for establishment of the axial budding pattern in haploid cells. Cooperates with other bud site selection proteins to recognize a spatial landmark during mitosis and they subsequently become a landmark for downstream polarity establishment factors that coordina [...] (1447 aa)
       
      0.699
YIL152W
Putative protein of unknown function (235 aa)
       
      0.699
YIH1
Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1- mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down- regulation of protein synthesis (PubMed-1512650 [...] (258 aa)
       
 
  0.648
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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