node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | ARP4 | YFL039C | YJL081C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.999 |
ACT1 | ARP6 | YFL039C | YLR085C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. | 0.978 |
ACT1 | IES6 | YFL039C | YEL044W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin-remodeling complex subunit IES6; Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; Belongs to the IES6 family. | 0.972 |
ACT1 | INO80 | YFL039C | YGL150C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription. | 0.999 |
ACT1 | RVB1 | YFL039C | YDR190C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly. | 0.999 |
ACT1 | SWC4 | YFL039C | YGR002C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ACT1 | SWR1 | YFL039C | YDR334W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.999 |
ACT1 | TTI1 | YFL039C | YKL033W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | TEL2-interacting protein 1; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies. | 0.428 |
ACT1 | VPS72 | YFL039C | YDR485C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting. | 0.993 |
ARP4 | ACT1 | YJL081C | YFL039C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.999 |
ARP4 | ARP6 | YJL081C | YLR085C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. | 0.962 |
ARP4 | IES6 | YJL081C | YEL044W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin-remodeling complex subunit IES6; Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; Belongs to the IES6 family. | 0.990 |
ARP4 | INO80 | YJL081C | YGL150C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription. | 0.999 |
ARP4 | RVB1 | YJL081C | YDR190C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly. | 0.999 |
ARP4 | SWC4 | YJL081C | YGR002C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ARP4 | SWR1 | YJL081C | YDR334W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.999 |
ARP4 | VPS72 | YJL081C | YDR485C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting. | 0.994 |
ARP6 | ACT1 | YLR085C | YFL039C | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.978 |
ARP6 | ARP4 | YLR085C | YJL081C | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.962 |
ARP6 | IES6 | YLR085C | YEL044W | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. | Chromatin-remodeling complex subunit IES6; Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; Belongs to the IES6 family. | 0.784 |