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MSS116 protein (Saccharomyces cerevisiae) - STRING interaction network
"MSS116" - DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns in Saccharomyces cerevisiae
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Known Interactions
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Predicted Interactions
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textmining
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protein homology
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MSS116DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation (664 aa)    
Predicted Functional Partners:
PRP22
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; Acts late in the splicing of pre-mRNA. Mediates the release of the spliced mRNA from spliceosomes (1145 aa)
   
 
  0.959
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (1237 aa)
     
      0.862
MSS18
Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5’ exon - intron junction; phenotype of intronless strain suggests additional functions; Involved in splicing of intron aI5-beta of the mitochondrial COX1 transcript (268 aa)
       
 
  0.847
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Required for pre-18S rRNA processing. May bind microtubules (511 aa)
     
 
  0.846
SUV3
ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear- mitochondrial interactions (737 aa)
     
 
  0.844
RRP3
Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA (501 aa)
   
 
0.815
NOG1
Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; Involved in the biogenesis of the 60S ribosomal subunit (647 aa)
     
 
  0.813
DHR2
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis; Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis (735 aa)
     
 
  0.805
KRE33
Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)- acetylcytidine (ac4C) at positions 1280 and 1773 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed-25086048, PubMed-25653167). Catalyzes the formation of ac4C at position 12 in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 f [...] (1056 aa)
     
 
  0.804
NOP15
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs (220 aa)
     
 
  0.803
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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