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RKM2 protein (Saccharomyces cerevisiae) - STRING interaction network
"RKM2" - Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RKM2Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at ’Lys-4’ and ’Lys-11’ (479 aa)    
Predicted Functional Partners:
RKM3
Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at ’Lys-40’ (552 aa)
           
  0.895
CTM1
Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth; Methyltransferase which mediates trimethylation of ’Lys- 78’ of cytochrome c (CYC1) (585 aa)
           
  0.894
RKM1
SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B); S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates ribosomal protein S18 (RPS18A and RPS18B) at ’Lys-48’ and dimethylates ribosomal protein L23 (RPL23A and RPL23B) at ’Lys-106’ and ’Lys-110’ (583 aa)
           
  0.893
RMT2
Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins (PubMed-9873020). Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at ’Arg-67’ (PubMed-11856739) (412 aa)
           
  0.892
EFM1
Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at ’Lys-30’ (585 aa)
           
  0.889
RKM4
Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at ’Lys-55’ (494 aa)
           
  0.869
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins; This protein binds directly to 26S ribosomal RNA (165 aa)
     
 
  0.793
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins; This protein binds directly to 26S ribosomal RNA (165 aa)
     
 
  0.793
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall (332 aa)
       
 
  0.731
SET5
Putative S-adenosylmethionine-dependent methyltransferase; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV (526 aa)
           
  0.674
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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