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PRP42 protein (Saccharomyces cerevisiae) - STRING interaction network
"PRP42" - U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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PRP42U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats; Essential component of the U1 snRNP particle, which recognizes and binds the 5’-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. U1 snRNP is cotranscriptionally recruited to intron-containing genes. Required for U1 snRNP biogenesis (544 aa)    
Predicted Functional Partners:
SNU56
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex; Component of the U1 snRNP particle, which recognizes and binds the 5’-splice site of pre-mRNA. Together with other non- snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (492 aa)
     
 
  0.988
SNU71
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; Component of the U1 snRNP particle, which recognizes and binds the 5’-splice site of pre-mRNA. Together with other non- snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (620 aa)
     
 
  0.979
YHC1
Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5’ splice site; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates comm [...] (231 aa)
       
 
  0.976
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces /.../iotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; Acts as a suppressor of mitochondrial splicing deficiencies when overexpressed. Could be a non-essential component of the mitochondrial splicing machinery (523 aa)
       
 
  0.970
PRP40
U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex; Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5’ splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5’ splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protei [...] (583 aa)
     
 
  0.969
SNP1
Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; Involved in nuclear mRNA splicing (300 aa)
       
 
  0.964
SMD3
Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Also binds telomerase RNA and is required for its accumulation (101 aa)
       
 
  0.952
MUD1
U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing; Involved in nuclear mRNA splicing. The principal role of the U1A is to help fold or maintain U1 RNA in an active configuration. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (298 aa)
       
 
  0.950
LUC7
Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5’ splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; Component of the U1 snRNP particle, which recognizes and binds the 5’-splice site of pre-mRNA. Together with other non- snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (261 aa)
     
 
  0.949
SMD1
Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Also binds telomerase RNA and is required for its accumulation (146 aa)
       
 
  0.946
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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