node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HIR1 | HIR2 | YBL008W | YOR038C | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores. | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia. | 0.999 |
HIR1 | YDL026W | YBL008W | YDL026W | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.536 |
HIR1 | YDR249C | YBL008W | YDR249C | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.536 |
HIR2 | HIR1 | YOR038C | YBL008W | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia. | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores. | 0.999 |
HIR2 | YDL026W | YOR038C | YDL026W | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.515 |
HIR2 | YDR249C | YOR038C | YDR249C | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.721 |
SAT4 | YDL026W | YCR008W | YDL026W | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.603 |
SAT4 | YDR249C | YCR008W | YDR249C | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.603 |
SLY1 | YDL026W | YDR189W | YDL026W | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.516 |
SLY1 | YDR249C | YDR189W | YDR249C | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.516 |
THR1 | YDL026W | YHR025W | YDL026W | Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.510 |
THR1 | YDR249C | YHR025W | YDR249C | Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.510 |
TOP1 | YDR249C | YOL006C | YDR249C | DNA topoisomerase 1; Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.559 |
YBR137W | YDL026W | YBR137W | YDL026W | UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene; Belongs to the UPF0303 family. | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.813 |
YBR137W | YDR249C | YBR137W | YDR249C | UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene; Belongs to the UPF0303 family. | Uncharacterized protein YDR249C; Putative protein of unknown function. | 0.810 |
YBR137W | YJR085C | YBR137W | YJR085C | UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene; Belongs to the UPF0303 family. | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress. | 0.579 |
YDL026W | HIR1 | YDL026W | YBL008W | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores. | 0.536 |
YDL026W | HIR2 | YDL026W | YOR038C | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia. | 0.515 |
YDL026W | SAT4 | YDL026W | YCR008W | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion. | 0.603 |
YDL026W | SLY1 | YDL026W | YDR189W | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex. | 0.516 |