node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HIR1 | HIR2 | YBL008W | YOR038C | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | 0.996 |
HIR1 | YDL026W | YBL008W | YDL026W | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.650 |
HIR1 | YDR249C | YBL008W | YDR249C | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | Uncharacterized protein YDR249C; Putative protein of unknown function | 0.650 |
HIR1 | YJR085C | YBL008W | YJR085C | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress | 0.450 |
HIR2 | HIR1 | YOR038C | YBL008W | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | 0.996 |
HIR2 | HIS6 | YOR038C | YIL020C | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts | 0.435 |
HIR2 | YDL026W | YOR038C | YDL026W | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.703 |
HIR2 | YDR249C | YOR038C | YDR249C | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | Uncharacterized protein YDR249C; Putative protein of unknown function | 0.705 |
HIR2 | YJR085C | YOR038C | YJR085C | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress | 0.517 |
HIS6 | HIR2 | YIL020C | YOR038C | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia | 0.435 |
HIS6 | YDL026W | YIL020C | YDL026W | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.570 |
HIS6 | YDR249C | YIL020C | YDR249C | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts | Uncharacterized protein YDR249C; Putative protein of unknown function | 0.570 |
SAT4 | YBR137W | YCR008W | YBR137W | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion | UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene; Belongs to the UPF0303 family | 0.452 |
SAT4 | YDL026W | YCR008W | YDL026W | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.712 |
SAT4 | YDR249C | YCR008W | YDR249C | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion | Uncharacterized protein YDR249C; Putative protein of unknown function | 0.712 |
SAT4 | YJR085C | YCR008W | YJR085C | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress | 0.570 |
SLY1 | YDL026W | YDR189W | YDL026W | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.650 |
SLY1 | YDR249C | YDR189W | YDR249C | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex | Uncharacterized protein YDR249C; Putative protein of unknown function | 0.650 |
SLY1 | YJR085C | YDR189W | YJR085C | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress | 0.450 |
THR1 | YDL026W | YHR025W | YDL026W | Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.657 |