STRINGSTRING
SEC20 protein (Saccharomyces cerevisiae) - STRING interaction network
"SEC20" - Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER in Saccharomyces cerevisiae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEC20Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (383 aa)    
Predicted Functional Partners:
UFE1
t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER; Syntaxin required for targeting and fusion of Golgi- derived retrograde transport vesicles with the ER (346 aa)
       
  0.999
SEC22
R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog; Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER (214 aa)
       
  0.998
USE1
Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (245 aa)
       
  0.994
YKT6
Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus (200 aa)
       
  0.984
TIP20
Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p; Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer- coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex (701 aa)
       
 
  0.982
BOS1
v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex (244 aa)
       
  0.969
BET1
Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex (142 aa)
       
  0.968
SED5
cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE) (340 aa)
       
  0.967
SFT1
Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment; Vesicle SNARE required for retrograde transport within the Golgi complex (97 aa)
         
  0.955
GOS1
v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. Rescues alpha- factor maturation defects (223 aa)
         
  0.949
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
Server load: low (3%) [HD]