| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BUR6 | SRF1 | YER159C | YDL133W | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | 0.471 |
| BUR6 | YDR509W | YER159C | YDR509W | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.441 |
| ECM8 | YDR509W | YBR076W | YDR509W | Non-essential protein of unknown function. | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.607 |
| GNP1 | YDR509W | YDR508C | YDR509W | High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication. | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.773 |
| RPP2A | SRF1 | YOL039W | YDL133W | 60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm. | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | 0.471 |
| RPP2A | YDR509W | YOL039W | YDR509W | 60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm. | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.402 |
| SRF1 | BUR6 | YDL133W | YER159C | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | 0.471 |
| SRF1 | RPP2A | YDL133W | YOL039W | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | 60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm. | 0.471 |
| SRF1 | YDR509W | YDL133W | YDR509W | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.759 |
| YDR509W | BUR6 | YDR509W | YER159C | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | 0.441 |
| YDR509W | ECM8 | YDR509W | YBR076W | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Non-essential protein of unknown function. | 0.607 |
| YDR509W | GNP1 | YDR509W | YDR508C | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication. | 0.773 |
| YDR509W | RPP2A | YDR509W | YOL039W | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm. | 0.402 |
| YDR509W | SRF1 | YDR509W | YDL133W | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. | 0.759 |