node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADF1 | AUA1 | YCL058W-A | YFL010W-A | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | 0.760 |
ADF1 | EMI1 | YCL058W-A | YDR512C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | 0.510 |
ADF1 | HUR1 | YCL058W-A | YGL168W | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Putative uncharacterized protein HUR1; Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene. | 0.475 |
ADF1 | IMO32 | YCL058W-A | YGR031W | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Probable alcohol acetyltransferase; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1. | 0.477 |
ADF1 | NAG1 | YCL058W-A | YGR031C-A | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32. | 0.568 |
ADF1 | PRP38 | YCL058W-A | YGR075C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Pre-mRNA-splicing factor 38; Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly; Belongs to the PRP38 family. | 0.510 |
ADF1 | VAM10 | YCL058W-A | YOR068C | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering. | 0.712 |
ATP23 | EMI1 | YNR020C | YDR512C | Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; Belongs to the peptidase M76 family. | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | 0.493 |
ATP23 | PHB1 | YNR020C | YGR132C | Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; Belongs to the peptidase M76 family. | Prohibitin-1; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR). | 0.782 |
AUA1 | ADF1 | YFL010W-A | YCL058W-A | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | 0.760 |
AUA1 | EMI1 | YFL010W-A | YDR512C | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | 0.513 |
AUA1 | HUR1 | YFL010W-A | YGL168W | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Putative uncharacterized protein HUR1; Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene. | 0.713 |
AUA1 | IMO32 | YFL010W-A | YGR031W | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Probable alcohol acetyltransferase; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1. | 0.487 |
AUA1 | NAG1 | YFL010W-A | YGR031C-A | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32. | 0.595 |
AUA1 | PRP38 | YFL010W-A | YGR075C | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Pre-mRNA-splicing factor 38; Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly; Belongs to the PRP38 family. | 0.511 |
AUA1 | VAM10 | YFL010W-A | YOR068C | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. | Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering. | 0.756 |
CHC1 | EMI1 | YGL206C | YDR512C | Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function. | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | 0.556 |
CHC1 | PHB1 | YGL206C | YGR132C | Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function. | Prohibitin-1; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR). | 0.575 |
EMI1 | ADF1 | YDR512C | YCL058W-A | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand. | 0.510 |
EMI1 | ATP23 | YDR512C | YNR020C | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology. | Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; Belongs to the peptidase M76 family. | 0.493 |