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API2 protein (Saccharomyces cerevisiae) - STRING interaction network
"API2" - Dubious open reading frame, unlikely to encode a protein in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
API2Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology (109 aa)    
Predicted Functional Partners:
YMR245W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (206 aa)
           
  0.749
YPL182C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W (127 aa)
           
  0.742
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies; May be involved in metabolic processes (108 aa)
           
  0.722
YER121W
Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy; May be involved in phosphatase regulation and/or generation of precursor metabolites and energy (114 aa)
           
  0.697
YJR012C
Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W (207 aa)
           
  0.642
YBR113W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 (160 aa)
           
  0.579
YGR182C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W (117 aa)
           
  0.549
SRF1
Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16-0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer’s patients; Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16-0 platelet activating factor (437 aa)
           
  0.508
VPS74
Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane [...] (345 aa)
           
  0.504
ACK1
Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria (623 aa)
           
  0.443
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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