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FIT1 protein (Saccharomyces cerevisiae) - STRING interaction network
"FIT1" - Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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FIT1Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space (528 aa)    
Predicted Functional Partners:
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Involved in the uptake of non-siderophore and siderohpore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space (153 aa)
           
  0.830
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation. Iron could interact directly with AFT1 and inhibits its activity (690 aa)
           
  0.745
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis (627 aa)
     
   
  0.742
AFT2
Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p; Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon (416 aa)
           
  0.719
FET3
Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper- dependent iron transport (636 aa)
           
  0.711
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C; Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis (620 aa)
     
   
  0.710
FTR1
High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; Permease for high affinity iron uptake (404 aa)
           
  0.700
ENB1
Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment; Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis (606 aa)
           
  0.697
FRE1
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (686 aa)
           
  0.697
HMX1
ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants; Plays an important role in the degradation of heme under conditions of iron deprivation (317 aa)
           
  0.697
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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