| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MPT5 | MTC7 | YGL178W | YEL033W | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | 0.475 |
| MTC7 | MPT5 | YEL033W | YGL178W | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | 0.475 |
| MTC7 | OCA5 | YEL033W | YHL029C | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | 0.480 |
| MTC7 | TMA23 | YEL033W | YMR269W | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | 0.478 |
| MTC7 | YEL008W | YEL033W | YEL008W | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism. | 0.680 |
| MTC7 | YGR069W | YEL033W | YGR069W | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Putative uncharacterized protein YGR069W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.751 |
| MTC7 | YMR031W-A | YEL033W | YMR031W-A | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.514 |
| MTC7 | YMR181C | YEL033W | YMR181C | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Uncharacterized protein YMR181C; Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication. | 0.734 |
| MTC7 | YNL143C | YEL033W | YNL143C | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Uncharacterized membrane protein YNL143C; Protein of unknown function; expressed at both mRNA and protein levels. | 0.643 |
| MTC7 | YNL179C | YEL033W | YNL179C | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Putative uncharacterized protein YNL179C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance. | 0.538 |
| MTC7 | YPL261C | YEL033W | YPL261C | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | Uncharacterized protein YPL261C; Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W. | 0.558 |
| OCA5 | MTC7 | YHL029C | YEL033W | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | 0.480 |
| OCA5 | TMA23 | YHL029C | YMR269W | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | 0.480 |
| OCA5 | YEL008W | YHL029C | YEL008W | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism. | 0.664 |
| OCA5 | YMR031W-A | YHL029C | YMR031W-A | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.516 |
| TMA23 | MTC7 | YMR269W | YEL033W | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | 0.478 |
| TMA23 | OCA5 | YMR269W | YHL029C | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | 0.480 |
| TMA23 | YEL008W | YMR269W | YEL008W | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism. | 0.650 |
| TMA23 | YMR031W-A | YMR269W | YMR031W-A | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.527 |
| YEL008W | MTC7 | YEL008W | YEL033W | Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism. | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant. | 0.680 |
