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PRO3 protein (Saccharomyces cerevisiae) - STRING interaction network
"PRO3" - Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis in Saccharomyces cerevisiae
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Known Interactions
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Predicted Interactions
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textmining
co-expression
protein homology
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PRO3Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis (286 aa)    
Predicted Functional Partners:
PRO2
Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis; Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (456 aa)
 
   
  0.975
PRO1
Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis; Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (428 aa)
 
   
  0.970
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source; Converts proline to delta-1-pyrroline-5-carboxylate (476 aa)
     
  0.968
PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism (575 aa)
         
  0.933
TYR1
Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels (452 aa)
         
  0.816
SEC27
Essential beta’-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta’-COP; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of di [...] (889 aa)
     
      0.816
THR4
Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (514 aa)
   
   
  0.786
HIS4
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis (799 aa)
   
   
  0.742
ACT1
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
     
   
  0.729
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p (863 aa)
         
  0.722
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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