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EMP65 protein (Saccharomyces cerevisiae) - STRING interaction network
"EMP65" - Putative protein of unknown function in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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EMP65Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins; May be involved in membrane protein folding (556 aa)    
Predicted Functional Partners:
SLP1
Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; May be involved in membrane protein folding (PubMed-19325107). Required for localization of MPS3 to the nuclear envelope (PubMed-23275891) (587 aa)
     
      0.891
GET4
Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20; May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane (312 aa)
       
 
  0.617
MDY2
Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes; Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos (212 aa)
       
 
  0.591
EMC5
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (141 aa)
           
  0.577
EMC6
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (108 aa)
           
  0.575
ENV10
Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene; Involved in vacuolar processing and morphology (181 aa)
     
   
  0.543
EMC2
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (292 aa)
           
  0.541
EMC3
Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (253 aa)
           
  0.515
NEM1
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard; Essential for the formation of a spherical nucleus and meiotic division. Catalytic component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates SMP2 (446 aa)
       
 
  0.515
LCL2
Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); Probable component of the endoplasmic reticulum- associated degradation (ERAD) pathway that acts upstream of HRD3 and USA1 (131 aa)
           
  0.514
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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