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PET122 protein (Saccharomyces cerevisiae) - STRING interaction network
"PET122" - Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
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protein homology
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PET122Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane; Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA (254 aa)    
Predicted Functional Partners:
PET54
Mitochondrial inner membrane protein; binds to the 5’ UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3 (293 aa)
       
 
  0.983
PET494
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane; Required for the expression of the mitochondrial gene for cytochrome c oxidase subunit III (COX3) (489 aa)
           
  0.955
COX3
Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Subunits I, II and III form the functional core of the enzyme complex (269 aa)
       
 
  0.953
MRP17
Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator (131 aa)
       
 
  0.937
PET127
Protein with a role in 5’-end processing of mitochondrial RNAs, located in the mitochondrial membrane; Could be a component of the mitochondrial translation system with a role in promoting accuracy of translational initiation (800 aa)
       
 
  0.913
PET111
Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane; Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2) (800 aa)
           
  0.891
PET309
Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1 (965 aa)
       
 
  0.889
COX2
Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (251 aa)
       
 
  0.862
COB
Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c (385 aa)
           
  0.842
PET123
Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator (318 aa)
       
 
  0.814
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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