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PUG1 protein (Saccharomyces cerevisiae) - STRING interaction network
"PUG1" - Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PUG1Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins; Involved in inducible protoporphyrin IX influx and heme efflux (303 aa)    
Predicted Functional Partners:
YDR034W-B
Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery (51 aa)
     
   
  0.596
FYV12
Protein of unknown function, required for survival upon exposure to K1 killer toxin; Involved in K1 killer toxin resistance (129 aa)
           
  0.578
YNL266W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C (139 aa)
           
  0.519
YJL028W
Protein of unknown function; may interact with ribosomes, based on co-purification experiments (111 aa)
           
  0.519
YGR228W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C (114 aa)
           
  0.519
YGL204C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (101 aa)
           
  0.519
YDR526C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (156 aa)
           
  0.519
TOG1
Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source; Required for growth on non-fermentable carbon sources (794 aa)
     
        0.503
RTP1
Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II. May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1. May also participate in the transport of RNA polymerase II through the nuclear pore complex (981 aa)
           
  0.489
VPS69
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect; Deletion causes a vacuolar protein sorting defect (106 aa)
           
  0.482
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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