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WWM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"WWM1" - WW domain containing protein of unknown function in Saccharomyces cerevisiae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
WWM1WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1; Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed (211 aa)    
Predicted Functional Partners:
URN1
Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase; Component of the spliceosome involved in mRNA processing (465 aa)
           
  0.579
AUA1
Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease; Involved in ammonia regulation of the GAP1 permease (94 aa)
     
   
  0.524
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact; Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity (68 aa)
           
  0.503
PRP40
U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex; Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5’ splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5’ splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protei [...] (583 aa)
           
  0.487
KSH1
Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish; Involved in the early part of the secretory pathway (72 aa)
           
  0.450
RSP5
E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates an /.../dy; ubiquitylates Sec23p; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general a [...] (809 aa)
       
 
  0.437
YNL190W
Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site; Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process (204 aa)
           
  0.418
YDR514C
Protein of unknown function that localizes to mitochondria; overexpression of YDR514C affects endocytic protein trafficking (483 aa)
           
  0.418
YFR006W
Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene (535 aa)
           
  0.414
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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