node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTT1 | DDR2 | YGR088W | YOL052C-A | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | 0.907 |
CTT1 | GRE1 | YGR088W | YPL223C | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication. | 0.779 |
CTT1 | HSP104 | YGR088W | YLL026W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation; Belongs to the ClpA/ClpB family. | 0.772 |
CTT1 | HSP12 | YGR088W | YFL014W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | 12 kDa heat shock protein; Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension. | 0.963 |
CTT1 | HSP26 | YGR088W | YBR072W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity. | 0.802 |
CTT1 | HSP42 | YGR088W | YDR171W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress. | 0.699 |
CTT1 | MSC1 | YGR088W | YML128C | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated. | 0.955 |
CTT1 | MSN2 | YGR088W | YMR037C | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Zinc finger protein MSN2; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress. | 0.847 |
CTT1 | RTC3 | YGR088W | YHR087W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Restriction of telomere capping protein 3; Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress. | 0.834 |
CTT1 | SSA3 | YGR088W | YBL075C | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | Heat shock protein SSA3; ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication. | 0.664 |
DDR2 | CTT1 | YOL052C-A | YGR088W | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | 0.907 |
DDR2 | GRE1 | YOL052C-A | YPL223C | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication. | 0.701 |
DDR2 | HSP12 | YOL052C-A | YFL014W | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | 12 kDa heat shock protein; Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension. | 0.938 |
DDR2 | HSP26 | YOL052C-A | YBR072W | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity. | 0.769 |
DDR2 | HSP42 | YOL052C-A | YDR171W | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress. | 0.632 |
DDR2 | MSC1 | YOL052C-A | YML128C | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated. | 0.824 |
DDR2 | MSN2 | YOL052C-A | YMR037C | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Zinc finger protein MSN2; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress. | 0.622 |
DDR2 | RTC3 | YOL052C-A | YHR087W | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | Restriction of telomere capping protein 3; Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress. | 0.669 |
GRE1 | CTT1 | YPL223C | YGR088W | Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication. | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. | 0.779 |
GRE1 | DDR2 | YPL223C | YOL052C-A | Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication. | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication. | 0.701 |