node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APL2 | APM2 | YKL135C | YHL019C | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | 0.999 |
APL2 | APS1 | YKL135C | YLR170C | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | 0.999 |
APL2 | MIL1 | YKL135C | YFL034W | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.683 |
APM2 | APL2 | YHL019C | YKL135C | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | 0.999 |
APM2 | APS1 | YHL019C | YLR170C | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | 0.999 |
APM2 | MIL1 | YHL019C | YFL034W | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.606 |
APS1 | APL2 | YLR170C | YKL135C | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | 0.999 |
APS1 | APM2 | YLR170C | YHL019C | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | 0.999 |
APS1 | MIL1 | YLR170C | YFL034W | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.695 |
ENV10 | MIL1 | YLR065C | YFL034W | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control; Belongs to the TMEM208 family. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.631 |
ENV10 | YDR018C | YLR065C | YDR018C | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control; Belongs to the TMEM208 family. | Uncharacterized acyltransferase YDR018C; Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication. | 0.640 |
FRS1 | MIL1 | YLR060W | YFL034W | Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.423 |
FYV12 | MIL1 | YOR183W | YFL034W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.539 |
GUP2 | MIL1 | YPL189W | YFL034W | Glycerol uptake protein 2; Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.536 |
MIL1 | APL2 | YFL034W | YKL135C | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress. | 0.683 |
MIL1 | APM2 | YFL034W | YHL019C | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | 0.606 |
MIL1 | APS1 | YFL034W | YLR170C | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. | 0.695 |
MIL1 | ENV10 | YFL034W | YLR065C | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control; Belongs to the TMEM208 family. | 0.631 |
MIL1 | FRS1 | YFL034W | YLR060W | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control. | 0.423 |
MIL1 | FYV12 | YFL034W | YOR183W | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.539 |