node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVT7 | MEP1 | YIL088C | YGR121C | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. | Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication. | 0.425 |
AVT7 | YFL040W | YIL088C | YFL040W | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.611 |
AVT7 | YKL050C | YIL088C | YKL050C | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. | Uncharacterized protein YKL050C; Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has a paralog, EIS1, that arose from the whole genome duplication. | 0.549 |
BUD17 | YFL040W | YNR027W | YFL040W | Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK). | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.470 |
FLX1 | RBH2 | YIL134W | YJR030C | Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family. | UPF0508 protein YJR030C; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication; Belongs to the UPF0508 family. | 0.531 |
FLX1 | YFL040W | YIL134W | YFL040W | Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.602 |
HXT14 | SPR2 | YNL318C | YOR214C | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication. | 0.535 |
HXT14 | YFL040W | YNL318C | YFL040W | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.498 |
MEP1 | AVT7 | YGR121C | YIL088C | Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication. | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. | 0.425 |
MEP1 | YFL040W | YGR121C | YFL040W | Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.463 |
QDR3 | YFL040W | YBR043C | YFL040W | Quinidine resistance protein 3; Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.513 |
RBH2 | FLX1 | YJR030C | YIL134W | UPF0508 protein YJR030C; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication; Belongs to the UPF0508 family. | Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.531 |
RBH2 | YFL040W | YJR030C | YFL040W | UPF0508 protein YJR030C; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication; Belongs to the UPF0508 family. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.517 |
SPR2 | HXT14 | YOR214C | YNL318C | Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication. | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.535 |
SPR2 | YFL040W | YOR214C | YFL040W | Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication. | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | 0.465 |
YFL040W | AVT7 | YFL040W | YIL088C | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. | 0.611 |
YFL040W | BUD17 | YFL040W | YNR027W | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK). | 0.470 |
YFL040W | FLX1 | YFL040W | YIL134W | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.602 |
YFL040W | HXT14 | YFL040W | YNL318C | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.498 |
YFL040W | MEP1 | YFL040W | YGR121C | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. | Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication. | 0.463 |