node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APM1 | APM2 | YPL259C | YHL019C | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | 0.616 |
APM1 | AQY3 | YPL259C | YFL054C | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | 0.705 |
APM1 | FPS1 | YPL259C | YLL043W | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | Glycerol uptake/efflux facilitator protein; Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.694 |
APM1 | MSN5 | YPL259C | YDR335W | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | Protein MSN5; Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog. | 0.748 |
APM1 | YNK1 | YPL259C | YKL067W | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress. | 0.647 |
APM2 | APM1 | YHL019C | YPL259C | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | 0.616 |
APM2 | AQY3 | YHL019C | YFL054C | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | 0.703 |
APM2 | FPS1 | YHL019C | YLL043W | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Glycerol uptake/efflux facilitator protein; Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.696 |
APM2 | MSN5 | YHL019C | YDR335W | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Protein MSN5; Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog. | 0.753 |
APM2 | YNK1 | YHL019C | YKL067W | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress. | 0.647 |
AQY3 | APM1 | YFL054C | YPL259C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. | 0.705 |
AQY3 | APM2 | YFL054C | YHL019C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family. | 0.703 |
AQY3 | BCY1 | YFL054C | YIL033C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation. | 0.816 |
AQY3 | FPS1 | YFL054C | YLL043W | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Glycerol uptake/efflux facilitator protein; Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.871 |
AQY3 | GUT1 | YFL054C | YHL032C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; Belongs to the FGGY kinase family. | 0.796 |
AQY3 | GUT2 | YFL054C | YIL155C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner. | 0.695 |
AQY3 | MSN5 | YFL054C | YDR335W | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Protein MSN5; Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog. | 0.650 |
AQY3 | RRP43 | YFL054C | YCR035C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress. | 0.911 |
AQY3 | YMR130W | YFL054C | YMR130W | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Putative protein of unknown function; YMR130W is not an essential gene; Belongs to the HAD-like hydrolase superfamily. | 0.788 |
AQY3 | YNK1 | YFL054C | YKL067W | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. | Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress. | 0.706 |