node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DSD1 | MPO1 | YGL196W | YGL010W | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | 0.449 |
DSD1 | OCA1 | YGL196W | YNL099C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | 0.463 |
DSD1 | OCA5 | YGL196W | YHL029C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | 0.470 |
DSD1 | VPS55 | YGL196W | YJR044C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.444 |
DSD1 | YCR101C | YGL196W | YCR101C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene. | 0.577 |
DSD1 | YDL109C | YGL196W | YDL109C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication. | 0.512 |
DSD1 | YDR132C | YGL196W | YDR132C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication. | 0.537 |
DSD1 | YGL242C | YGL196W | YGL242C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.550 |
DSD1 | YLR108C | YGL196W | YLR108C | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | BTB/POZ domain-containing protein YLR108C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication. | 0.483 |
MNN4 | MPO1 | YKL201C | YGL010W | Protein MNN4; Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; To yeast YJR061w. | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | 0.699 |
MNN4 | YGL242C | YKL201C | YGL242C | Protein MNN4; Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; To yeast YJR061w. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.407 |
MPO1 | DSD1 | YGL010W | YGL196W | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate. | 0.449 |
MPO1 | MNN4 | YGL010W | YKL201C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Protein MNN4; Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; To yeast YJR061w. | 0.699 |
MPO1 | OCA1 | YGL010W | YNL099C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | 0.478 |
MPO1 | OCA5 | YGL010W | YHL029C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family. | 0.481 |
MPO1 | VPS55 | YGL010W | YJR044C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.471 |
MPO1 | YCR101C | YGL010W | YCR101C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene. | 0.520 |
MPO1 | YDL109C | YGL010W | YDL109C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication. | 0.516 |
MPO1 | YDR132C | YGL010W | YDR132C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication. | 0.539 |
MPO1 | YGL242C | YGL010W | YGL242C | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.542 |