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GEP7 protein (Saccharomyces cerevisiae) - STRING interaction network
"GEP7" - Protein of unknown function in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GEP7Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Involved in respiratory growth and required for cell survival in the absence of prohibitins or GEM1 (287 aa)    
Predicted Functional Partners:
BRL1
Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export; Involved in mRNA and protein export from nucleus (471 aa)
           
  0.697
LAP2
Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro) (671 aa)
           
  0.571
MRN1
RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES). Probably involved in translational regulation (612 aa)
           
  0.540
COS6
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (381 aa)
           
  0.540
CCM1
Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport; RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (864 aa)
           
  0.514
REE1
Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle; Functions in the galactose metabolic pathway via the GAL83 protein and that it may control the level of ENO1 (198 aa)
           
  0.487
YOR302W
CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA; Arginine attenuator peptide (AAP) that has a regulatory role in the production of arginine-specific carbamoyl phosphate synthetase. Encoded by an upstream open reading frame (uORF) within the 5’-leader region of arginine-specific carbamoyl phosphate synthetase small chain (CPA1) mRNA, it attenuates the translation of the downstream CPA1 ORF. In the presence of high concentrations of arginine, ribosomes translating the uORF encoding AAP stall at the termination codon, resulting in reduced translation from th [...] (25 aa)
           
  0.480
UBP7
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; Involved in the sorting of ubiquitinated cargo proteins at the multivesicular body (MVB) (1071 aa)
           
  0.446
PRP39
U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats; Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5’- splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome (629 aa)
           
  0.416
GID7
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions; Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase) (745 aa)
           
  0.414
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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