node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCD1 | TOS8 | YHR144C | YGL096W | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.563 |
DCD1 | YHR145C | YHR144C | YHR145C | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.747 |
DCD1 | YHR219W | YHR144C | YHR219W | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated | Putative uncharacterized protein yhr219w; Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII | 0.717 |
RSF2 | TOS8 | YJR127C | YGL096W | Respiration factor 2; Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.564 |
TOS8 | DCD1 | YGL096W | YHR144C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated | 0.563 |
TOS8 | RSF2 | YGL096W | YJR127C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Respiration factor 2; Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress | 0.564 |
TOS8 | XBP1 | YGL096W | YIL101C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress | 0.601 |
TOS8 | YGL101W | YGL096W | YGL101W | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | HD domain-containing protein YGL101W; Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication | 0.717 |
TOS8 | YHP1 | YGL096W | YDR451C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Homeobox protein YHP1; Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication | 0.571 |
TOS8 | YHR145C | YGL096W | YHR145C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | 0.691 |
TOS8 | YHR177W | YGL096W | YHR177W | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Uncharacterized protein YHR177W; Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest | 0.682 |
TOS8 | YHR210C | YGL096W | YHR210C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Uncharacterized isomerase YHR210C; Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions; Belongs to the aldose epimerase family | 0.552 |
TOS8 | YHR217C | YGL096W | YHR217C | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Putative uncharacterized protein YHR217C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R | 0.618 |
TOS8 | YHR219W | YGL096W | YHR219W | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | Putative uncharacterized protein yhr219w; Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII | 0.613 |
XBP1 | TOS8 | YIL101C | YGL096W | Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.601 |
YGL101W | TOS8 | YGL101W | YGL096W | HD domain-containing protein YGL101W; Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.717 |
YHP1 | TOS8 | YDR451C | YGL096W | Homeobox protein YHP1; Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.571 |
YHR145C | DCD1 | YHR145C | YHR144C | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated | 0.747 |
YHR145C | TOS8 | YHR145C | YGL096W | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication | 0.691 |
YHR145C | YHR210C | YHR145C | YHR210C | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Uncharacterized isomerase YHR210C; Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions; Belongs to the aldose epimerase family | 0.748 |