node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG1 | ALG14 | YBR110W | YBR070C | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant | 0.993 |
ALG1 | RSN1 | YBR110W | YMR266W | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | Calcium permeable stress-gated cation channel; Uncharacterized protein RSN1; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane | 0.503 |
ALG1 | YGL114W | YBR110W | YGL114W | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.569 |
ALG14 | ALG1 | YBR070C | YBR110W | UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | 0.993 |
ALG14 | RSN1 | YBR070C | YMR266W | UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant | Calcium permeable stress-gated cation channel; Uncharacterized protein RSN1; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane | 0.532 |
ALG14 | YGL114W | YBR070C | YGL114W | UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.572 |
DUR1,2 | SMP3 | YBR208C | YOR149C | Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress | GPI mannosyltransferase 4; Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure | 0.487 |
DUR1,2 | YGL114W | YBR208C | YGL114W | Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.595 |
OPT1 | PTR2 | YJL212C | YKR093W | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | 0.948 |
OPT1 | PTR3 | YJL212C | YFR029W | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | SPS-sensor component PTR3; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p | 0.489 |
OPT1 | SMP3 | YJL212C | YOR149C | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | GPI mannosyltransferase 4; Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure | 0.573 |
OPT1 | YGL114W | YJL212C | YGL114W | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.903 |
OPT2 | PTR2 | YPR194C | YKR093W | Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | 0.944 |
OPT2 | YGL114W | YPR194C | YGL114W | Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.791 |
PTR2 | OPT1 | YKR093W | YJL212C | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | 0.948 |
PTR2 | OPT2 | YKR093W | YPR194C | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth | 0.944 |
PTR2 | PTR3 | YKR093W | YFR029W | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | SPS-sensor component PTR3; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p | 0.813 |
PTR2 | SSY5 | YKR093W | YJL156C | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | SPS-sensor serine protease component SSY5; Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p | 0.526 |
PTR2 | YGL114W | YKR093W | YGL114W | Proton-dependent oligopeptide transporter, pot family; Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p | Putative oligopeptide transporter ygl114w; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters | 0.615 |
PTR3 | OPT1 | YFR029W | YJL212C | SPS-sensor component PTR3; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family | 0.489 |