STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MRM2Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. (320 aa)    
Predicted Functional Partners:
MRM1
rRNA methyltransferase 1, mitochondrial; Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
  
 
 0.954
MTG1
Mitochondrial GTPase 1; Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals.
   
 
 0.949
MTG2
GTPase MTG2, mitochondrial; Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
   
 
 0.946
RTC6
54S ribosomal protein RTC6, mitochondrial; Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress; Belongs to the bacterial ribosomal protein bL36 family.
    
 
 0.922
GCD10
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression.
   
 
 0.815
MRPL17
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.808
IMG2
Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49.
   
 
 0.793
MRPL10
Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels.
   
 
 0.786
IMG1
Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome.
   
 
 0.775
MRPL9
Mitochondrial ribosomal protein of the large subunit.
  
 
 0.768
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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