| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM23 | RMD9 | YJL131C | YGL107C | Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss. | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication. | 0.420 |
| AIM23 | RSM28 | YJL131C | YDR494W | Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss. | Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation. | 0.913 |
| AIM23 | YGL159W | YJL131C | YGL159W | Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.835 |
| CAR1 | CYS4 | YPL111W | YGR155W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | 0.477 |
| CAR1 | MCY1 | YPL111W | YGR012W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Putative cysteine synthase; localized to the mitochondrial outer membrane. | 0.495 |
| CAR1 | TRP5 | YPL111W | YGL026C | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; In the N-terminal section; belongs to the TrpA family. | 0.732 |
| CAR1 | YGL159W | YPL111W | YGL159W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.819 |
| CWC15 | YGL159W | YDR163W | YGL159W | Pre-mRNA-splicing factor CWC15; Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; Belongs to the CWC15 family. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.598 |
| CYS4 | CAR1 | YGR155W | YPL111W | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.477 |
| CYS4 | MCY1 | YGR155W | YGR012W | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | Putative cysteine synthase; localized to the mitochondrial outer membrane. | 0.850 |
| CYS4 | TRP5 | YGR155W | YGL026C | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; In the N-terminal section; belongs to the TrpA family. | 0.995 |
| CYS4 | YGL159W | YGR155W | YGL159W | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.570 |
| MCY1 | CAR1 | YGR012W | YPL111W | Putative cysteine synthase; localized to the mitochondrial outer membrane. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.495 |
| MCY1 | CYS4 | YGR012W | YGR155W | Putative cysteine synthase; localized to the mitochondrial outer membrane. | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant. | 0.850 |
| MCY1 | TRP5 | YGR012W | YGL026C | Putative cysteine synthase; localized to the mitochondrial outer membrane. | Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; In the N-terminal section; belongs to the TrpA family. | 0.924 |
| MCY1 | YGL159W | YGR012W | YGL159W | Putative cysteine synthase; localized to the mitochondrial outer membrane. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.570 |
| PET112 | RMD9 | YBL080C | YGL107C | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; Belongs to the GatB/GatE family. GatB subfamily. | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication. | 0.691 |
| PET112 | RSM28 | YBL080C | YDR494W | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; Belongs to the GatB/GatE family. GatB subfamily. | Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation. | 0.528 |
| PET112 | YGL159W | YBL080C | YGL159W | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; Belongs to the GatB/GatE family. GatB subfamily. | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. | 0.597 |
| RMD9 | AIM23 | YGL107C | YJL131C | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication. | Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss. | 0.420 |
