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CUP2 protein (Saccharomyces cerevisiae) - STRING interaction network
"CUP2" - Copper-binding transcription factor in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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CUP2Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; Trans-acting regulatory protein that activates transcription of the CUP1 gene (metallothionein) in response to copper ions. Binds to the CUP1 UAS sequence 5’-GCTTCTTTTCCGCTGA- 3’. Binds DNA only in presence of copper or silver. Copper seems to alter the conformation of the protein (225 aa)    
Predicted Functional Partners:
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins (61 aa)
           
  0.937
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C (61 aa)
           
  0.913
CRS5
Copper-binding metallothionein, required for wild-type copper resistance; Critical role in copper (specific) homeostasis and detoxification. May protect by directly chelating and sequestering copper ions (69 aa)
           
  0.877
YBR056W-A
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B (66 aa)
     
        0.762
SOD1
Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (154 aa)
           
  0.694
ALG5
UDP-glucose-dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (334 aa)
       
 
  0.673
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; Required for high affinity copper (probably reduced Cu I) transport into the cell (241 aa)
           
  0.653
HSF1
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures (833 aa)
       
 
  0.603
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source. Can also transport methylamine. The affinity of MEP1 is about twenty times lower than that of MEP2. MEP3 has the lowest affinity (492 aa)
           
  0.591
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation. Iron could interact directly with AFT1 and inhibits its activity (690 aa)
       
 
  0.584
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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