node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GRX7 | YGL177W | YBR014C | YGL177W | Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.601 |
GRX7 | YLR358C | YBR014C | YLR358C | Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication. | Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W. | 0.442 |
MET18 | RAD10 | YIL128W | YML095C | DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family. | DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Belongs to the ERCC1/RAD10/SWI10 family. | 0.859 |
MET18 | YGL177W | YIL128W | YGL177W | DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.535 |
NAT3 | YGL177W | YPR131C | YGL177W | Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; Belongs to the acetyltransferase family. GNAT subfamily. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.607 |
NAT3 | YLR358C | YPR131C | YLR358C | Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; Belongs to the acetyltransferase family. GNAT subfamily. | Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W. | 0.470 |
RAD10 | MET18 | YML095C | YIL128W | DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Belongs to the ERCC1/RAD10/SWI10 family. | DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family. | 0.859 |
RAD10 | YGL177W | YML095C | YGL177W | DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Belongs to the ERCC1/RAD10/SWI10 family. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.448 |
RLF2 | YGL177W | YPR018W | YGL177W | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.470 |
SRP40 | YGL177W | YKR092C | YGL177W | Suppressor protein SRP40; Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.831 |
SRP40 | YLR358C | YKR092C | YLR358C | Suppressor protein SRP40; Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140. | Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W. | 0.698 |
VMA6 | YGL177W | YLR447C | YGL177W | Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits. | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.564 |
VMA6 | YLR358C | YLR447C | YLR358C | Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits. | Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W. | 0.421 |
YGL177W | GRX7 | YGL177W | YBR014C | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication. | 0.601 |
YGL177W | MET18 | YGL177W | YIL128W | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family. | 0.535 |
YGL177W | NAT3 | YGL177W | YPR131C | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; Belongs to the acetyltransferase family. GNAT subfamily. | 0.607 |
YGL177W | RAD10 | YGL177W | YML095C | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Belongs to the ERCC1/RAD10/SWI10 family. | 0.448 |
YGL177W | RLF2 | YGL177W | YPR018W | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription. | 0.470 |
YGL177W | SRP40 | YGL177W | YKR092C | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Suppressor protein SRP40; Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140. | 0.831 |
YGL177W | VMA6 | YGL177W | YLR447C | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits. | 0.564 |