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SKI8 protein (Saccharomyces cerevisiae) - STRING interaction network
"SKI8" - Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome in Saccharomyces cerevisiae
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SKI8Ski complex component and WD-repeat protein, mediates 3’-5’ RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype; Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3’-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation o [...] (397 aa)    
Predicted Functional Partners:
SKI3
Ski complex component and TPR protein, mediates 3’-5’ RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5’-3’ mRNA decay; Component of the SKI complex involved in 3’-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon (1432 aa)
       
  0.999
SKI2
Ski complex component and putative RNA helicase, mediates 3’-5’ RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5’-3’ mRNA decay; RNA helicase component of the SKI complex involved in 3’-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon (1287 aa)
       
  0.999
SKI7
Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3’-5’ RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype; Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3’-to-5’ mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3’-to-5’ mRNA-decay (NMD). May recognize a stalled 80S ribo [...] (747 aa)
       
 
  0.976
SPO11
Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The action of SPO11 is important in setting off a regulatory chain of events encompassing 5’ to 3’ resection. When there are no SPO11-DSBs, resection of a site specific VDE-DSB takes place but it is faster than in wild- [...] (398 aa)
       
 
  0.961
CDC73
Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated /.../ G-less-based run-on (GLRO) assay; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA- binding proteins. Involved in elongation. It regulates 3’-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has [...] (393 aa)
     
 
  0.958
PAF1
Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by /.../g to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA- binding proteins. Involved in elongation. It regulates 3’-end formation of snR47 by modulating the recruitment or stable ass [...] (445 aa)
     
 
  0.949
LEO1
Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA- binding proteins. Involved in elongation. It regulates 3’-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histon [...] (464 aa)
     
 
  0.927
CSL4
Exosome non-catalytic core component; involved in 3’-5’ RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1); Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ [...] (292 aa)
     
 
  0.924
CTR9
Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to mai /.../SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA- binding proteins. Involved in elongation. It regulates 3’-end formation of snR47 by modulating the recruitment or stable association of NRD1 and [...] (1077 aa)
       
 
  0.913
REC104
Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination; Potential transcriptional regulator that is required to activate expression of a number of early meiotic genes including HOP1 (182 aa)
       
 
  0.909
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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