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ZRT1 protein (Saccharomyces cerevisiae) - STRING interaction network
"ZRT1" - Zinc-regulated transporter 1 in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
co-expression
protein homology
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ZRT1Zinc-regulated transporter 1; High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; Belongs to the ZIP transporter (TC 2.A.5) family (376 aa)    
Predicted Functional Partners:
ZRT3
Zinc-regulated transporter 3; Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency (503 aa)
     
 
  0.992
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family (346 aa)
     
 
  0.983
ZAP1
Zinc-responsive transcriptional regulator ZAP1; Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains (880 aa)
     
 
  0.980
FET4
Low-affinity Fe(II) transporter of the plasma membrane; Belongs to the FET4 family (552 aa)
     
   
  0.955
ZPS1
Protein ZPS1; Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH; Belongs to the ZPS1 family (249 aa)
     
   
  0.953
ZRC1
Zinc/cadmium resistance protein; Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication (442 aa)
     
 
  0.946
ZRG17
Protein ZRG17; Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency (605 aa)
       
 
  0.896
COT1
Cobalt uptake protein COT1; Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication (439 aa)
     
 
  0.885
MSC2
Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids (724 aa)
     
 
  0.880
NRG2
Probable transcriptional regulator NRG2; Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose (220 aa)
           
  0.789
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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