node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPB2 | RPB3 | YOR151C | YIL021W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
RPB2 | RPB5 | YOR151C | YBR154C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.999 |
RPB2 | RPB7 | YOR151C | YDR404C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB2 | RPB9 | YOR151C | YGL070C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.999 |
RPB2 | RPO21 | YOR151C | YDL140C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB2 | SPT15 | YOR151C | YER148W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.994 |
RPB2 | TFA1 | YOR151C | YKL028W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening. | 0.996 |
RPB2 | TFA2 | YOR151C | YKR062W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIE small subunit; involved in RNA polymerase II transcription initiation; Belongs to the TFIIE beta subunit family. | 0.996 |
RPB2 | TFG1 | YOR151C | YGR186W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
RPB2 | TFG2 | YOR151C | YGR005C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |
RPB3 | RPB2 | YIL021W | YOR151C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | 0.999 |
RPB3 | RPB5 | YIL021W | YBR154C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.999 |
RPB3 | RPB7 | YIL021W | YDR404C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB3 | RPB9 | YIL021W | YGL070C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.999 |
RPB3 | RPO21 | YIL021W | YDL140C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB3 | SPT15 | YIL021W | YER148W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.995 |
RPB3 | TFA1 | YIL021W | YKL028W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening. | 0.995 |
RPB3 | TFA2 | YIL021W | YKR062W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TFIIE small subunit; involved in RNA polymerase II transcription initiation; Belongs to the TFIIE beta subunit family. | 0.990 |
RPB3 | TFG1 | YIL021W | YGR186W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
RPB3 | TFG2 | YIL021W | YGR005C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |