node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP1 | ACS2 | YKL192C | YLR153C | Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p. | Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.517 |
ACP1 | YGR015C | YKL192C | YGR015C | Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p. | Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion. | 0.625 |
ACS2 | ACP1 | YLR153C | YKL192C | Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family. | Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p. | 0.517 |
ACS2 | OYE2 | YLR153C | YHR179W | Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family. | NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. | 0.525 |
ACS2 | YGR015C | YLR153C | YGR015C | Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family. | Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion. | 0.622 |
ARO8 | ATF1 | YGL202W | YOR377W | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | 0.513 |
ARO8 | EEB1 | YGL202W | YPL095C | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication. | 0.603 |
ARO8 | EHT1 | YGL202W | YBR177C | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication. | 0.415 |
ARO8 | IAH1 | YGL202W | YOR126C | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily. | 0.596 |
ARO8 | YGR015C | YGL202W | YGR015C | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion. | 0.696 |
ATF1 | ARO8 | YOR377W | YGL202W | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. | 0.513 |
ATF1 | ATF2 | YOR377W | YGR177C | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Alcohol O-acetyltransferase 2; Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking. | 0.485 |
ATF1 | EEB1 | YOR377W | YPL095C | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication. | 0.925 |
ATF1 | EHT1 | YOR377W | YBR177C | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication. | 0.924 |
ATF1 | IAH1 | YOR377W | YOR126C | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily. | 0.904 |
ATF1 | OYE2 | YOR377W | YHR179W | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. | 0.593 |
ATF1 | SLI1 | YOR377W | YGR212W | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin. | 0.507 |
ATF1 | YGR015C | YOR377W | YGR015C | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion. | 0.944 |
ATF2 | ATF1 | YGR177C | YOR377W | Alcohol O-acetyltransferase 2; Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking. | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism. | 0.485 |
ATF2 | EEB1 | YGR177C | YPL095C | Alcohol O-acetyltransferase 2; Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking. | Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication. | 0.642 |