node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATO2 | JEN1 | YNR002C | YKL217W | Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication. | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | 0.662 |
ATO2 | YGR067C | YNR002C | YGR067C | Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.519 |
CMR3 | SDD4 | YPR013C | YPR022C | Putative zinc finger protein; YPR013C is not an essential gene. | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.441 |
CMR3 | YGR067C | YPR013C | YGR067C | Putative zinc finger protein; YPR013C is not an essential gene. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.513 |
ECM13 | YGR067C | YBL043W | YGR067C | Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.526 |
JEN1 | ATO2 | YKL217W | YNR002C | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication. | 0.662 |
JEN1 | SFC1 | YKL217W | YJR095W | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization. | 0.781 |
JEN1 | YGR067C | YKL217W | YGR067C | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.557 |
MSN1 | YGR067C | YOL116W | YGR067C | Protein MSN1; Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.530 |
NOP7 | YGR067C | YGR103W | YGR067C | Pescadillo homolog; Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.474 |
PRE4 | YGR067C | YFR050C | YGR067C | Beta 7 subunit of the 20S proteasome; Belongs to the peptidase T1B family. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.453 |
SDD4 | CMR3 | YPR022C | YPR013C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Putative zinc finger protein; YPR013C is not an essential gene. | 0.441 |
SDD4 | YGR067C | YPR022C | YGR067C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.814 |
SFC1 | JEN1 | YJR095W | YKL217W | Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization. | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | 0.781 |
SFC1 | YGR067C | YJR095W | YGR067C | Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization. | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | 0.592 |
YGR067C | ATO2 | YGR067C | YNR002C | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication. | 0.519 |
YGR067C | CMR3 | YGR067C | YPR013C | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | Putative zinc finger protein; YPR013C is not an essential gene. | 0.513 |
YGR067C | ECM13 | YGR067C | YBL043W | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication. | 0.526 |
YGR067C | JEN1 | YGR067C | YKL217W | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC [...] | 0.557 |
YGR067C | MSN1 | YGR067C | YOL116W | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. | Protein MSN1; Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress. | 0.530 |